Premature termination of variable gene rearrangement in B lymphocytes from X-linked agammaglobulinemia.
نویسندگان
چکیده
X-linked agammaglobulinemia (XLA) results from failure of B lymphocyte development. Immature B cells from a patient with XLA were found to produce truncated mu and delta immunoglobulin H chains encoded by D-JH-C (mu delta). The 5' terminal sequence of cDNA encoding the H chains is composed of D-JH with the characteristic GGTTTGAAG/CACTGTG consensus sequence utilized for VH gene rearrangement upstream, and a leader sequence that serves for translation of this intermediate stage of rearrangement. Failure of variable region gene rearrangement may underlie the failure of B lymphoid development in XLA.
منابع مشابه
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 81 6 شماره
صفحات -
تاریخ انتشار 1988